- Best Paper Award 2023: "Detection of in vivo mutagenicity in rat liver samples using error-corrected sequencing techniques (45:30)"
- Check out the new article collection Article Collection of Papers Related to Oxidatively Damaged Bases Dedicated to Susumu Nishimura
- Check out new article collection Research on Genes and Environment by the Malaysian Society of Toxicology
- Updated Aims & Scope: to enhance the quality of Genes and Environment and its contents, the Journal has updated and revised its Aims and Scope.
What's new
[Featured Article]
Detection of in vivo mutagenicity in rat liver samples using error-corrected sequencing techniques
Kazuki Izawa, Masataka Tsuda, Takayoshi Suzuki, Masamitsu Honma & Kei-ichi Sugiyama
Mutagenicity, the potential of chemicals to cause mutations and cancer, is crucial for safety assessments. In vivo animal models, particularly rats, are essential due to their similar metabolic pathways to humans and higher responsiveness to carcinogens. Transgenic rodents (TGRs) are commonly used in mutation assays but are labor-intensive and limited to detecting transgene mutations. A new method for directly detecting in vivo mutagenicity in rats is needed, with next-generation sequencing (NGS) based error-corrected sequencing showing promise.
[Featured Article]
Genome-wide somatic mutation analysis of sinonasal adenocarcinoma with and without wood dust exposure
Lauri J. Sipilä, Riku Katainen, Mervi Aavikko, Janne Ravantti, Iikki Donner, Rainer Lehtonen, Ilmo Leivo, Henrik Wolff, Reetta Holmila, Kirsti Husgafvel-Pursiainen & Lauri A. Aaltonen
Sinonasal adenocarcinoma is a rare cancer, encompassing two different entities, the intestinal-type sinonasal adenocarcinoma (ITAC) and the non-intestinal-type sinonasal adenocarcinoma (non-ITAC). Occurrence of ITAC is strongly associated with exposure to hardwood dusts. In countries with predominant exposure to softwood dust the occurrence of sinonasal adenocarcinomas is lower and the relative amount of non-ITACs to ITACs is higher. The molecular mechanisms behind the tumorigenic effects of wood dust remain largely unknown.
Read this article: Volume 46, Article number: 12 (2024)
Article collections and Special Issues
- Article Collection of Papers Related to Oxidatively Damaged Bases Dedicated to Susumu Nishimura
- Research on Genes and Environment by the Malaysian Society of Toxicology
- Lessons Learned from Japanese Association for Cancer Prevention and Future Opportunities
- Current topics in China for Environmental Mutagen Research
- G&E Best Paper Award collection
- Special Issue in memory of Takashi Sugimura
- Asian Conference on Environmental Mutagens (ACEM2019)
- Article collection: Meeting Reports: collection of various meeting reports published in G&E
- Article collection: Genotoxicity Tests
- JEMS Open Symposia 2017&2018: “Challenges of Young Scientists”
- 10th Anniversary Special Issue
- JEMS Open Symposium 2015: “Life Style and Cancer”
- Asian Conference on Environmental Mutagens (ACEM2014)
About the Editor
Editor-in-Chief
Masami Yamada studied bacterial genetics and got a PhD degree from Osaka University. Since 1990, using genetic engineering techniques, she has constructed many strains from standard tester strains for the Ames test at the National Institute of Health Sciences, Tokyo. Such strains are useful for research fields on environmental mutagens.
Strain requests come to her every year from domestic, Asia, Europe, North America, South America, and other countries. Currently, she teaches Biology and Genetic Engineering at National Defense Academy of Japan.
Articles
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Genome-wide somatic mutation analysis of sinonasal adenocarcinoma with and without wood dust exposure
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Application of image-recognition techniques to automated micronucleus detection in the in vitro micronucleus assay
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Astaxanthin suppresses the malignant behaviors of nasopharyngeal carcinoma cells by blocking PI3K/AKT and NF-ÎşB pathways via miR-29a-3p
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The spectrum of TP53 mutations in Rwandan patients with gastric cancer
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Low-dose radiation from A-bombs elongated lifespan and reduced cancer mortality relative to un-irradiated individuals
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The micronucleus test—most widely used in vivo genotoxicity test—
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Mechanism and regulation of DNA damage recognition in nucleotide excision repair
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Mechanisms of interstrand DNA crosslink repair and human disorders
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The health effects of radon and uranium on the population of Kazakhstan
Aims and scope
Genes and Environment is an open-access, peer-reviewed journal that aims to accelerate communications among global scientists working in the fields of genes and environment. The journal welcomes papers dealing with those topics that are relevant to the environment, such as mutagenesis and carcinogenesis, genomics and epigenetics, molecular epidemiology and genetic toxicology, and regulatory sciences.
About JEMS
The mission of the Japanese Environmental Mutagen and Genome Society (JEMS) is to discover how environmental mutagens affect all organisms, and to promote and apply this knowledge to protect human health and our environment. JEMS was founded in 1972, and since then the society has hosted annual conferences and open symposia on timely topics. The society is a member of the Asian Association of the Environmental Mutagen Societies and the International Association of Environmental Mutagenesis and Genomics Societies.
Acknowledgement and information
-Publication of Genes and Environment is partly supported by the Japan Society of Promotion of Science Grant-in-Aid for Publication of Scientific Research Results, aka KAKENHI. (Grant Number 17HP2002).
-Genes and Environment archive of papers published before 2015 are available at: https://www.jstage.jst.go.jp/browse/jemsge
Genes and Environment is an official journal of The Japanese Environmental Mutagen and Genome Society (JEMS).
2022 Citation Impact
1.7 - 2-year Impact Factor
1.9 - 5-year Impact Factor
0.563 - SNIP (Source Normalized Impact per Paper)
0.537 - SJR (SCImago Journal Rank)
2023 Speed
7 days submission to first editorial decision for all manuscripts (Median)
91 days submission to accept (Median)
2023 Usage
314,686 downloads
181 Altmetric mentions